近5年代表性论文
1. Jun Lv#, Hui Wang#, Xiaoting Cheng#, Yuxin Chen#, Daqi Wang#, Longlong Zhang, Qi Cao, Honghai Tang, Shaowei Hu, Kaiyu Gao, Mengzhao Xun, Jinghan Wang, Zijing Wang, Biyun Zhu, Chong Cui, Ziwen Gao, Luo Guo, Sha Yu, Luoying Jiang, Yanbo Yin, Jiajia Zhang, Bing Chen, Wuqing Wang*, Renjie Chai*(并列通讯作者）, Zheng-Yi Chen*, Huawei Li*, and Yilai Shu*. AAV1-hOTOF Gene Therapy for Autosomal Recessive Deafness 9: a single-arm trial. Lancet, doi:10.1016/S0140-6736(23)02874-X, 2024(IF:168.9)
2. Yangnan Hu#, Jiayue Xing#, Hui Zhang#, Xinyi Pang#, Yabo Zhai#, Hong Cheng, Dongyu Xu, Menghui Liao, Yanru Qi, Danqi Wu, Bin Zhang, Lin Cheng*, Bo Chu*, Chen Zhang*, Yuanjin Zhao*, Renjie Chai*（最后并列通讯作者）. Electroacoustic responsive cochlea-on-a-chip. Advanced Materials, e2309002, 2018(IF:32.086)
3. Weiwei Cui#, Meng Guo#, Dong Liu#, Peng Xiao, Chuancheng Yang, Haidi Huang，Chunhui Liang, Yinghong Yang, Xiaolong Fu, Yudan Zhang, Jiaxing Liu, Shuang Shi, Jingjing Cong, Zili Han, Yunfei Xu, Lutao Du, Chengqian Yin, Yongchun Zhang, Jinpeng Sun, Wei Gu*, Renjie Chai*(并列通讯作者）, Shu Zhu* and Bo Chu*. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nature Cell Biology, DOI:10.1038/s41556-023-01314-6, 2024(IF:21.3)
4. Zhanhang Guo#, Yunhao Wu#, Bo Chen, Mengdie Kong, Peng Xie, Yan Li, Liu Dongfang*, Renjie Chai*(并列通讯作者）, Ning Gu*. Superparamagnetic iron oxide nanoparticle regulates microbiota-gut-inner ear axis for hearing protection. National Science Review, nwae100, 2024(IF:20.6)
5. Jieyu Qi#, Fangzhi Tan#, Liyan Zhang#, Ling Lu#, Shanzhong Zhang#, Yabo Zhai#, Yicheng Lu#, Xiaoyun Qian#, WenXiu Dong, Yinyi Zhou, Ziyu Zhang, Xuehan Yang, Lulu Jiang, Chaorong Yu, Jiancheng Liu, Tian Chen, Lianqiu Wu, Chang Tan, Sijie Sun, Huaien Song, Yilai Shu*, Lei Xu*, Xia Gao*, Huawei Li*, Renjie Chai*（最后并列通讯作者）. AAV-mediated gene therapy restores hearing in patients with DFNB9 Deafness. Advanced Science, e2306788, 2024 (IF:17.521)
6. Ziyi Liu#, Hanbing Zhang#, Xiuli Bi , Yachun An, Jun Hu , Na Guo , Fengyue Dong, Guodong Hong, Yu Xiao , Wen Li, Xiaoxu Zhao, Siwei Guo, Xiaohan Zhang, Renjie Chai*(并列通讯作者), Xiaolong Fu *. Inhibition of Gpx4-mediated Ferroptosis Alleviates Cisplatin-Induced Hearing Loss in C57BL/6 mice. Molecular Therapy, S1525- 0016(24)00098-4, 2024 (IF:12.4)
7. Jieyu Qi#, Liyan Zhang#, Xiaohan Wang, Xin Chen, Yiyuan Li, Tian Wang*, Peina Wu*, Renjie Chai*（最后并列通讯作者）. Modeling, applications and challenges of inner ear organoid. Smart Medicine, e20220028, 2024(IF:0)
8. Qiuhan Sun#, Liyan Zhang#, Tian Chen#, Nianci Li#, Fangzhi Tan#,*, Xingliang Gu, Yinyi Zhou, Ziyu Zhang, Yicheng Lu, Jie Lu, Xiaoyun Qian*, Bing Guan*, Jieyu Qi*, Fanglei Ye*, Renjie Chai*（最后并列通讯作者）. AAV-mediated Gpm6b expression supports hair cell reprogramming. Cell Proliferation, e13620, 2024. (IF: 8.755)
9. Lin Cheng#, Suyue Sun#, Heli Wang#, Chang Zhao#, Xiaowen Tian#, Ying Liu, Ping Fu, Zhenhua Shao*, Renjie Chai*(并列通讯作者）, Wei Yan*. Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2. Signal Transduction and Targeted Therapy, 8(1):364, 2023(IF:38.104)
10. Jie Zhao#, Hong Fu#, Jingjing Yu#, Weiqi Hong#, Xiaowen Tian#, Jieyu Qi#, Suyue Sun, Chang Zhao, ChaoWu, Zheng Xu, Lin Cheng, Renjie Chai*(并列通讯作者）, Wei Yan*, Xiawei Wei*, Zhenhua Shao*. Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nature Communications, 14(1):962, 2023 (IF:17.694)
11. Hong Chen#, Hui Zhang#, Yanhong Dai#, Haofang Zhu, Guodong Hong, Chengwen Zhu, Xiaoyun Qian*, Renjie Chai*(并列通讯作者）, Xia Gao*, and Yuanjin Zhao*. Magnetic Hydrogel Microrobots Delivery System for Deafness Prevention. Advanced Functional Materials, 2303011, 2023(IF:19.924)
12. Yuhua Zhang#, Qiaojun Fang#, Hongfeng Wang#, Jieyu Qi, Shan Sun, Menghui Liao, Yunhao Wu, Yangnan Hu, Pei Jiang, Cheng Cheng , Xiaoyun Qian, Mingliang Tang, Wei Cao, Shang Xiang, Chen Zhang, Jianming Yang*, Xia Gao*, Zheng Ying*, Renjie Chai*（最后并列通讯作者）.Increased mitophagy protects cochlear hair cells from aminoglycoside-induced damage. Autophagy, 19(1):75-91, 2023 (IF:13.391)
13. Jieyu Qi#,*, Liyan Zhang#, Fangzhi Tan#,*, Yang Zhang#, Yinyi Zhou, Ziyu Zhang, Hongyang Wang, Chaorong Yu, Lulu Jiang, Jiancheng Liu, Tian Chen, Lianqiu Wu, Shanzhong Zhang, Sijie Sun, Shan Sun*, Ling Lu*, Qiuju Wang*, Renjie Chai*（最后并列通讯作者）. Pre-clinical efficacy and safety evaluation of AAV-OTOF in DFNB9 mouse model and non-human primate. Advanced Science, e2306201, 2023 (IF:17.521)
14. Hui Zhang#, Hong Chen#, Ling Lu#, Huan Wang*, Yuanjin Zhao*, Renjie Chai*（最后并列通讯作者）. Natural Multifunctional Silk Microcarriers for Noise-Induced Hearing Loss Therapy. Advanced Science, e2305215, 2023 (IF:17.521)
15. Dong Liu#, Chun-hui Liang#, Bin Huang#, Xiao Zhuang#, Weiwei Cui, Li Yang, Yinghong Yang, Yudan Zhang, Xiaolong Fu, Xiaoju Zhang, Lutao Du, Wei Gu, Xiangdong Wang, Chengqian Yin*, Renjie Chai*(并列通讯作者）, Bo Chu*. Tryptophan metabolism acts as a new anti-ferroptotic pathway to mediate tumour growth. Advanced Science, e2204006, 2023 (IF:17.521)
16. Guodong Hong#, Xiaolong Fu#,*, Xin Chen#, Liyan Zhang#, Xuan Han, Shuqin Ding, Ziyi Liu, Liuli Bi, Wen Li, Miao Chang, Ruifeng Qiao, Siwei Guo, Hailong Tu, Renjie Chai*（最后并列通讯作者）. Dyslexia-related hearing loss occurs mainly through the abnormal spontaneous electrical activity of spiral ganglion neurons. Advanced Science, e2205754, 2023 (IF:17.521)
17. Xiaolong Fu#,*, Peifeng Wan#, Ling Lu#, Yingcui Wan, Ziyi Liu, Guodong Hong, Shengda Cao, Xiuli Bi, Jing Zhou, Ruifeng Qiao, Siwei Guo, Yu Xiao, Bingzheng Wang, Miao Chang, Wen Li, Peipei Li, Aizhen Zhang, Jin Sun, Renjie Chai*(并列通讯作者）, Jiangang Gao*. Peroxisome deficiency in cochlear hair cells causes hearing loss by deregulating BK channels. Advanced Science, e2300402, 2023 (IF:17.521)
18. Guoqiang Sun#, Yandong Zheng#, Xiaolong Fu#, Weiqi Zhang#, Jie Ren#,Shuai Ma, Shuhui Sun, Xiaojuan He, Qiaoran Wang, Zhejun Ji, Fang Cheng, Kaowen Yan, Ziyi Liu, Juan Carlos Izpisua Belmonte, Jing Qu*, Si Wang*, Renjie Chai*（并列通讯作者）,Guanghui Liu*. Single-cell transcriptomic Atlas of mouse cochlear aging. Protein & Cell, 14(3):180-201, 2023 (IF: 15.328)
19. Jieyu Qi#,*, Fangzhi Ta#,*, Liyan Zhang#, Yinyi Zhou, Ziyu Zhang, Qiuhan Sun, Nianci Li, Yuan Fang, Xin Chen, Yunhao Wu, Guisheng Zhong*, Renjie Chai*（最后并列通讯作者）. Critical role of TPRN rings in the stereocilia for hearing. Molecular Therapy, 32(1):204-217, 2023 (IF:12.4)
20. Hui Zhang, Huan Wang, Baojie Wen, Ling Lu, Yuanjin Zhao*, Renjie Chai*（最后并列通讯作者）. Ultrasound-responsive composited conductive silk conduits for peripheral nerve regeneration. Small Structures, 2300045, 2023 (IF: 11.343)
21. Lin Shi#, Guodong Hong#, Chuntao Chen*, Xueqian Li, Heng Zhang, Renjie Chai*(并列通讯作者), Dongping Sun*. Growth of spiral ganglion neurons induced by graphene oxide/oxidized bacterial cellulose composite hydrogel. Carbohydrate Polymers, 311: 120749, 2023 (IF：10.723）
22. Yunhao Wu#,*, Jingwen Zhang#, Qiuping Liu, Zhuang Miao, Renjie Chai*(并列通讯作者), Wenyong Chen*. Development of Chinese herbal medicine for sensorineural hearing loss. Acta Pharmaceutica Sinica B, 14(2):455-467, 2023 (IF：14.5）
23. Lin Xia#, Xiaolong Zhao#, Xiangyu Ma#, Yangnan Hu, Yuan Zhang, Siyu Li, Jie Wang*, Yuanjin Zhao*, Renjie Chai*（最后并列通讯作者）. Controllable growth of spiral ganglion neurons by magnetic colloidal nanochains. Nano Today, 44:101507, 2022(IF:18.962)
24. Yong Tao#, Xiaoyi Liu#, Liu Yang#, Cenfeng Chu, Fangzhi Tan, Zehua Yu, Junzi Ke, Xiang Li, Xiaofei Zheng, Xingle Zhao, Jieyu Qi, Chao-Po Lin, Renjie Chai*(并列通讯作者), Guisheng Zhong*, Hao Wu*. AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration. Signal Transduction and Targeted Therapy, 7(1):109, 2022(IF:38.104)
25. Hui Zhang#, Dongyu Xu#, Yong Zhang*, Minli Li*, Renjie Chai*（最后并列通讯作者）. Silk fibroin hydrogels for biomedical applications. Smart Medicine, DOI: 10.1002/SMMD.20220011, 2022(IF:0)
26. Xiaolong Fu, Peipei Li, Linqing Zhang,Yuning Song，Yachun An，Aizhen Zhang，Wenwen Liu，Chao Ye, Yuan Zhang, Rongyu Yue, Xiaoyang Sun, Renjie Chai*(并列通讯作者), Haibo Wang*,Jiangang Gao*. Activation of Rictor/mTORC2 signaling acts as a new pivotal strategy to protect against sensorineural hearing loss. PNAS, 119(10):e2107357119, 2022(IF:12.779)
27. Lingna Guo#, Wenxuan Dai#, Zhengrong Xu#, Qiaoyi Liang, Eliot T. Miller, Shengju Li, Xia Gao, Maude W. Baldwin, Renjie Chai*（并列通讯作者）, and Qian Li*. Evolution of brain-expressed biogenic amine receptors into olfactory trace amine-associated receptors. Molecular Biology and Evolution, 39(3):msac006,2022(IF:8.8)
28. Zhong Zhang#, Gao Shan#, Yangnan Hu#,Xin Chen, Cheng Cheng, Xiaolong Fu, Shasha Zhang, Xinlin Wang, Yuwei Che, Chen Zhang, Renjie Chai*（唯一通讯作者）.Ti3C2TxMXene Composite 3D Hydrogel Potentiates mTOR signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids. Advanced Science, e2203557, 2022 (IF:17.521)
29. Shuai Wang#, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi, Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu, Renjie Chai*（并列通讯作者）, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science, 9(4):e2104789, 2022 (IF:17.521)
30. Lijun Cai, Cheng Zhao, Hanxu Chen, Lu Fan, Yuanjin Zhao*, Xiaoyun Qian*, Renjie Chai*（最后并列通讯作者）. Suction-cup-inspired adhesive micromotors for drug delivery. Advanced Science, 9(1):e2103384, 2022 (IF:17.521)
31. Yangnan Hu#, Zhuoyue Chen#, Hongyang Wang#,Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu*, Yuanjin Zhao*, Renjie Chai*（最后并列通讯作者）.Conductive Nerve Guidance Conduits Based on Morpho Butterfly Wings for Peripheral Nerve Repair. ACS Nano, doi:10.1021/acsnano.1c11627, 2022(IF: 18.027) （科技部网站推荐论文）
32. Menghui Liao#, Yangnan Hu#, Yuhua Zhang, Kaichen Wang, Qiaojun Fang, Yanru Qi, Yingbo Shen, Hong Cheng, Xiaolong Fu, Mingliang Tang*, Shan Sun*, Xia Gao*, Renjie Chai*（最后并列通讯作者）. 3D Ti3C2Tx MXene-matrigel with electroacoustic stimulation to promote the growth of spiral ganglion neurons. ACS Nano, DOI: 10.1021/acsnano.2c06306, 2022(IF: 18.027) （国家自然科学基金委推荐论文）
33. Shuai Wang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-Ging Ong, Shijun Hu*, Renjie Chai*（并列通讯作者）, Yongming Wang*. Identification of SaCas9 orthologs containing a conserved serine residue that determines simple NNGG PAM recognition. PLoS Biology, 20(11):e3001897, 2022(IF:9.593)
34. Hui Zhang, Jiahui Guo, Yu Wang, Luoran Shang*, Renjie Chai*（并列通讯作者）, Yuanjin Zhao*. Natural polymer-derived bio-scaffolds for peripheral nerve regeneration. Advanced Functional Materials, 2203829, 2022(IF:19.924)
35. Rongrong Guo#, Miao Xiao#, Wanyu Zhao#, Shan Zhou, Yangnan Hu, Menghui Liao, Shengping Wang, Xiaowei Yang*, Renjie Chai*（并列通讯作者）, Mingliang Tang*. 2D Ti3C2Tx MXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells. Acta Biomaterialia, 139:105-117, 2022(IF:10.633) （ESI高被引论文）
36. Yangnan Hu#, Wei Chen#, Haiyan Yin#, Xiaoyan Chen, Jiaying Cai, Jiamin Guo, Shan Zhou, Renjie Chai*（并列通讯作者）, Mingliang Tang*. Super-aligned carbon nanotubes and GelMA hydrogel composite scaffolds promote spiral ganglion neuron growth and orientation. Materials Today Nano, 18,100181, 2022(IF：13.364)
37. Hao Wei#, Zhuoyue Chen#, Yangnan Hu#, Wei Cao#, Xiaofeng Ma, Chen Zhang, Xia Gao, Xiaoyun Qian*, Yuanjin Zhao*, Renjie Chai*（最后并列通讯作者）. Topographically Conductive Butterfly Wing Substrates for Directed Spiral Ganglion Neuron Growth. Small, e2102062,2021 (IF: 15.153)（Small期刊当期封面论文,国家自然科学基金委推荐论文）
38. Changxiu Qu#, Chunyou Mao#, Peng Xiao#, Qingya Shen#, YaNi Zhong#, Fan Yang#, Dan-Dan Shen, Xiaona Tao, Huibing Zhang, Xu Yan, RuJia Zhao, Junyan He, Ying Guan, Chao Zhang, Guihua Hou, PengJu Zhang, Guige Hou, Zijian Li, Xiao Yu, Renjie Chai*（并列通讯作者）, YouFei Guan, JinPeng Sun*, Yan Zhang*. Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor 2 (EP2). Science Advances, 7(14):eabf1268,2021 (IF:14.957)
39. Wenwen Liu#, Lei Xu#, Xue Wang, Daogong Zhang, Gaoying Sun, Man Wang, Mingming Wang, Yuechen Han*, Renjie Chai*（并列通讯作者）, Haibo Wang*. PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage. Autophagy, 1-23, 2021 (IF：13.391) （ESI高被引论文）
40. Zuhong He#, Ming Li#, Qiaojun Fang#, Fuling Liao#, Shengyu Zou, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Xiaoxiang Xu, Sen Chen, Yu Sun, Renjie Chai*（并列通讯作者）, Weijia Kong*. FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway. Autophagy, 1-22, 2021 (IF：13.391) （ESI高被引论文）
41. Yan Chen#, Yuyan Gu#, Yige Li#, GengLin Lia, Renjie Chai*（并列通讯作者）, Wenyan Li*, Huawei Li*. Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea. Cell Reports, 35(3):109016, 2021 (IF：9.995) （ESI高被引论文）
42. Cheng Zhao, Guopu Chen, Huan Wang, Yuanjin Zhao*, Renjie Chai*（最后并列通讯作者）. Bio-inspired intestinal scavenger from microfluidic electrospray for detoxifying lipopolysaccharide. Bioactive Materials, 27;6(6):1653-1662, 2021 (IF:16.874)
43. Shanying Han#, Yueshuang Xu#, Jie Sun, Yufeng Liu, Yuanjin Zhao*, Weiguo Tao*, Renjie Chai*（最后并列通讯作者）. Isolation and analysis of extra cellular vesicles in a Morpho butterfly wing-integrated micro vortex biochip. Biosensors and Bioelectronics, 154:112073, 2020 (IF:12.545)
44. Jiahui Guo, Yunru Yu, Lingyu Sun, Zhuohao Zhang, Yuanjin Zhao*, Renjie Chai*（并列通讯作者）, Keqing Shi*. Bio-inspired multicomponent carbon nanotube microfibers from microfluidics for supercapacitor. Chemical Engineering Journal, 397:125517, 2020(IF:16.744)
45. Zuhong He#, Shengyu Zou#, Ming Li, Fuling Liao, Xia Wu, Haiying Sun, Xueyan Zhao, Yujuan Hu, Dan Li, Xiaoxiang Xu, Sen Chen, Yu Sun*, Renjie Chai*（并列通讯作者）, Weijia Kong*. The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways. Redox Biology, 28:101364, 2020 (IF:10.787)（Faculty1000推荐，ESI高被引论文）
46. Shasha Zhang#, Yuan Zhang, Lingna Guo, Zhong Zhang, Ying Dong, Buwei Shao, Jieyu Qi, Han Zhou, Weijie Zhu, Xiaoqian Yan, Guodong Hong, Liyan Zhang, Xiaoli Zhang, Mingliang Tang, Chunjie Zhao, Xia Gao, Renjie Chai*（唯一通讯作者）. Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea. Cellular and Molecular Life Sciences, 77(7), 1401-1419, 2020(IF:9.207)（Faculty1000推荐，ESI高被引论文）
47. Keqi, Fan#, Yiyuan Li#, Haoli Wang, Xintao Mao, Jinxin Guo, Xintao Mao, Fei, Wang, Lingjie Huang, Yining Li, Xiangyu Ma, Zhengjun Gao, Wei Chen, Dandan Qian, Wenjin Xue, Qian Cao, Lei Zhang, Li Shen,Long Zhang, Chao Tong, Jiangyan Zhong, Wei Lu, Ling Lu, Ke-ming Ren, Guisheng Zhong, Yuan Wang,Mingliang Tang, XinHua Feng, Renjie Chai*（并列通讯作者）, Jin Jin*. Stress-induced metabolic disorder in peripheral CD4+ T cells leads to anxiety-like behavior. Cell, 179, 864–879, 2019(IF:66.850)（Faculty1000推荐，Cell正刊年度最佳论文，国家自然科学基金委推荐论文）
48. Jieyu Qi#, Yan Liu#, Cenfeng Chu, Xin Chen, Weijie Zhu, Yilai Shu, Shuijin He*, Renjie Chai*（并列通讯作者）, Guisheng Zhong*. A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells. Cell Discovery, 5:12, 2019(IF:38.079) （国家自然科学基金委推荐论文）
49. Fangzhi Tan#*, Cenfeng Chu#, Jieyu Qi#, Wenyan Li#, Dan You, Ke Li, Xing Chen, Weidong Zhao, Cheng Cheng, Xiaoyi Liu, Yunbo Qiao, Bing Su, Shuijin He, Chao Zhong, Huawei Li*, Renjie Chai*（并列通讯作者）, Guisheng Zhong*. AAV-ie enables safe and efficient gene transfer to inner ear cells. Nature Communications, 10(1):3733, 2019(IF:17.694)（国家自然科学基金委推荐论文）
50. Jinping Zhao#, Mingliang Tang#, Jing Cao, Dan Ye, Xudong Guo, Jiajie Xi, Yi Zhou, Yuchen Xia, Jing Qiao, Renjie Chai*（并列通讯作者）, Xiaowei Yang* and Jiuhong Kang*. Structurally Tunable Reduced Graphene Oxide Substrate Maintains Mouse Embryonic Stem Cell Pluripotency. Advanced Science, 6(12):1802136, 2019 (IF: 17.521)
51. Yan Liu#, Jieyu Qi#, Xin Chen#, Mingliang Tang#, Cenfeng Chu, Weijie Zhu, Hui Li, Cuiping Tian, Guang Yang, Chao Zhong, Zhang Ying, Guangjian Ni, Shuijin He*, Renjie Chai*（并列通讯作者）, Guisheng Zhong*. Critical role of spectrin in hearing development and deafness. Science Advances, 5(4):eaav7803, 2019(IF: 14.957) （国家自然科学基金委推荐论文）
